Antimicrobial potential of filamentous fungi growing on renewable substrates

The bioprospecting of secondary metabolites with antimicrobial action produced by filamentous fungi isolated from various ecosystems using agro-industrial residues is considerable importance, since it reconciles the discovery new agents reduction environmental impacts adding economic value to wastes. present paper investigated potential for production alternative media based on corn steep liquor, cassava wastewater and glycerol as substrates in different combinations. From 15 assayed preliminary screening, Paecilomyces variotii UCP 0334, Aspergillus flavus 0316, foetidus 0360, niger 1064 e sp. 74M4 showed higher activity against all tested bacteria. After submerged fermentation containing glycerol, P. 0334 exhibitted greater spectrum inhibition halos ranging 7 28 mm diameter Gram negative positive bacteria regardless culture medium type. It worth mentioning that (CWWG) inhibitory 3 9 mm. On other hand, liquor (CSLG) favored biomass yield fungi. These results stimulate further studies identification characterization selected a view discovering drugs.